Novo Nordisk CagriSema Phase 3 results — need advice

Short answer first, then the reasoning. The gap between trial results and real-world results is consistent and it is not fraud. Trial participants get titration by protocol, scheduled contact, free drug and dietetic support; removing that infrastructure costs a few percentage points every time it has been measured. When your own curve sits below the published mean, that is the likeliest explanation before anything about you or your material.

Dr.RenalNash said:

The gap between trial results and real-world results is consistent and it is not fraud.

Agreed, and subgroup analyses deserve particular suspicion. With enough subgroups something is significant by chance, and pre-registered subgroups are a different animal from ones found afterwards.

Correct me if the detail matters more than I have assumed.

mike_mod said:

Trying to work out whether the combination is doing something a higher single-agent dose would not, or whether it is a more expensive way to reach the…

Same experience, arrived at from the opposite direction.

From the other side of the consultation, briefly. Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third retelling.