chris_chi24 said:Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak.
Can confirm. Same sequence, different timescale. I had assumed I was the exception until I read this.
chris_chi24 said:Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak.
Adding the part of the answer the thread has not reached. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.
One concrete data point for the thread. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.
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Shop Reference StandardsA narrower follow-up, since the general answer is now clear:
What would you measure differently if you were starting again?
TrialTracker_MD said:Say what you would expect to see if you were wrong, before you look.
I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.