GLP-1 receptor agonists and thyroid C-cell concerns — what worked for you?

Dr.SurgeonPGH said:

The pharmacokinetics explain nearly every practical question asked here.

I read this differently from Dr.SurgeonPGH, on substance rather than tone. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.

The figures, for anyone assembling their own picture. Numbers worth memorising for this class: Tmax one to three days for the weekly peptides, terminal half-life about a week for semaglutide and about five days for tirzepatide, steady state at four to five half-lives, subcutaneous bioavailability high enough that site choice is irrelevant.

TirzTom said:

Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the…

Adding the part of the answer the thread has not reached. The distinction that resolves most of these threads is between what is true on average and what is true for one person. Both are real; they answer different questions and get quoted as if they were the same one.

One thing that is still open after LondonLisa’s answer:

Which effects tachyphylax and which persist, because the answer explains why tolerability improves while the appetite effect keeps working?

Reporting back.

Update — tachyphylaxis to the gastric effect, persistence of the appetite effect. Two curves, and I had been watching the wrong one.