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ForumsPsychological & BehavioralGrief over lost years — 6 month update

Grief over lost years — 6 month update

mel_PDX Wed, Sep 10, 2025 at 10:17 PM 20 replies 1,600 viewsPage 1 of 4
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mel_PDX
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Sep 10, 2025 at 10:17 PM#1

Posting this because the summary going around does not say what the paper says, and the difference matters for how people here are using it.

The mental-health dimension is under-measured in the trial literature and the reports here are consistent enough to take seriously. On the positive side: reduced anxiety around food, better self-image, more confidence. On the difficult side: grief for the years lost, identity disruption, relationships built around eating, and the loss of food as a coping mechanism with nothing put in its place. Rarer but real: anhedonia and emotional flatness. Regulators have started asking for validated patient-reported outcomes in this class; the existing data gap is not evidence of absence.

Where I think it is weakest: the comparator does most of the work in how this gets reported, and it is not the comparator most people think they are citing.

The bit I cannot resolve on my own is how people separated a drug effect from the ordinary consequences of a large deficit and disrupted sleep, because I cannot. Not looking for reassurance. Looking for the part I have got wrong.

Note on sourcing:
Figures above are from the primary publication rather than the press summary. If a number here disagrees with one you have, post yours and we will work out which of us is reading a secondary source.
12 7Dr.NateNeph, PharmD_Rodriguez, julia.endo and 9 others
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Dr.ObesityLA
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Sep 10, 2025 at 10:37 PM#2
mel_PDX said:
The mental-health dimension is under-measured in the trial literature and the reports here are consistent enough to take seriously.

Recovering from an eating disorder and using mental health: this is a complex situation and I want to be transparent about it.

I have a history of binge eating disorder. My psychiatrist, therapist, and prescribing doctor all collaborate on my care. The GLP-1 agonist has actually been therapeutic — it removes the biological urgency of binge impulses without relying on restriction.

This is NOT appropriate for all ED patients. Anorexia, bulimia, and restrictive EDs require different approaches. But for BED specifically, the evidence and my personal experience are positive. Always involve your mental health team.

11 6KarenAZ_mom, zoe_NC, Dr.ObesityLA and 8 others
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Dr.LipidDallas
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Sep 10, 2025 at 10:57 PM#3
mel_PDX said:
The mental-health dimension is under-measured in the trial literature and the reports here are consistent enough to take seriously.

Pushing back on mel_PDX here. I would be careful about how confidently the flatness reports get attributed. Rapid weight loss, a large deficit and disrupted sleep produce low mood on their own, and separating that from a drug effect is genuinely hard.

10 5cory_ATX, lori_vegas, Dr.PulmRoch and 7 others
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Dr.DermMIA
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Sep 10, 2025 at 11:17 PM#4
Dr.LipidDallas said:
I would be careful about how confidently the flatness reports get attributed.
Dr.LipidDallas said:
...mental health should only be used alongside therapy...

I'd say therapy should be AVAILABLE to all GLP-1 patients, but requiring it as a precondition for treatment would create an access barrier.

Not everyone can afford therapy. Not everyone needs it. Some people do just fine with medication + lifestyle changes. But for those with emotional eating, body image issues, or disordered eating history, therapy is extremely valuable.

My recommendation: make mental health screening part of the initial assessment, offer therapy as a recommended adjunct, but don't gatekeep medication access behind it.

9 4PeptideChemSF, A1cHero_PHX, Dr.RenalNash and 6 others
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RegAffairsDC
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Sep 11, 2025 at 1:07 AM#5
Dr.ObesityLA said:
Recovering from an eating disorder and using mental health: this is a complex situation and I want to be transparent about it.

Adding a me-too, because a thread of one person's experience is not much use.

8 3gary_naperville, sean_dublin, hannah_MT and 5 others
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