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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPsychological & BehavioralGrief over lost years — 6 month update Page 2

Grief over lost years — 6 month update

mel_PDX Wed, Sep 10, 2025 at 10:17 PM 20 replies 1,600 viewsPage 2 of 4
hank_denver
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Sep 11, 2025 at 2:57 AM#6
mel_PDX said:
The mental-health dimension is under-measured in the trial literature and the reports here are consistent enough to take seriously.

One year anniversary on mental health — reflections:

What I wish I'd known: the side effects are temporary, the benefits compound over time, protein is more important than I thought, and the mental health aspect needs as much attention as the physical.

What surprised me: how much my relationship with food changed, the cascade of health improvements beyond weight, and how supportive this community is.

What I'd do differently: start therapy earlier, prioritize resistance training from day 1, and stop comparing my progress to others. Everyone's journey is unique.

Last edited: Sep 11, 2025 at 6:57 AM
7 2ingrid_STO, pete_nash, hank_denver and 4 others
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SleepDoc_PDX
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Sep 2024
Portland, OR
Sep 11, 2025 at 4:47 AM#7

A narrower follow-up, since the general answer is now clear:

How would you tell the difference between that and the alternative explanation?

6 1hank_denver, carlos_SATX, sophie_paris and 3 others
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Dr.CardioMD
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Cleveland, OH
Sep 11, 2025 at 6:37 AM#8
hank_denver said:
One year anniversary on mental health — reflections: What I wish I'd known: the side effects are temporary, the benefits compound over time, protein…

When to call your doctor about mental health side effects — a reference I wish I'd had:

Call immediately:

  • Severe abdominal pain (could be pancreatitis)
  • Vision changes (thyroid concern)
  • Lump in neck (thyroid nodule)
  • Severe vomiting/can't keep fluids down for 24h+

Schedule an appointment:

  • Persistent nausea beyond 4 weeks
  • Significant hair loss
  • Mood changes or depression
  • Gallbladder symptoms (RUQ pain after eating)
5 0tony_orlando, Dr.NephBHM_UK, kim_atl_prep and 2 others
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mel_PDX
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Portland, OR
Sep 11, 2025 at 8:27 AM#9

Reporting back.

Follow-up — I put something in the gap where food used to be rather than waiting for the gap to close on its own. That was the part nobody told me.

4 24BiostatsBrad, PeptideSynthNJ, Dr.KarenChen and 1 other
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JessicaM_2024
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Portland, OR
Sep 11, 2025 at 5:13 PM#10
Dr.CardioMD said:
When to call your doctor about mental health side effects — a reference I wish I'd had: Call immediately: Severe abdominal pain (could be…

Mood changes on mental health: I want to be transparent — I went through a rough patch emotionally around month 2. Not depression exactly, but a weird flatness. Food was my main coping mechanism and without that, I had to develop new ones.

Therapy has been essential. I'd strongly recommend anyone starting GLP-1 therapy also invest in mental health support. The physical transformation is only half the journey.

44 19kevin_tulsa, Dr.PainCLE, mike_mealprep and 41 others
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