Adding the numbers, since they settle part of this. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.
Following on from PedsEndoPhilly — and this may be the naive question:
Whether the fasting requirement is as strict in practice as the label implies, and what people actually see when they get it wrong?
lisa_labSD said:Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…
There is a second half to this that has not been said yet. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.
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Follow-up: moving the tablet to the moment I wake, before anything else, was the whole fix. The dose never changed.
Dr.PeteFamMed said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
No disagreement with Dr.PeteFamMed. One condition attached. The absorption variability is real, but it partly averages out over weeks — the steady-state trough is less erratic than any single day would suggest. Where it bites is in the first fortnight, when people conclude the tablet does nothing.