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ForumsOral GLP-1 AgonistsOrforglipron Phase 2 weight loss data — 12 month update Page 3

Orforglipron Phase 2 weight loss data — 12 month update

JenPlateau Wed, Sep 11, 2024 at 8:13 PM 29 replies 2,118 viewsPage 3 of 6
amsterdam_pete
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Sep 15, 2024 at 1:32 PM#11
LipidDoc_ATL said:
Relative and absolute effects need reading together.

Agreed, and the size of the effect matters as much as its existence. Something real and small gets treated here as though it were real and decisive.

23 21JakeSmashed95, NauseaFreeNow, SteveThurs and 20 others
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nick_newbie
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Sep 15, 2024 at 4:27 PM#12
labquiet_amy said:
The manufacturing argument is the underrated one.

Saving this. It is the first explanation that did not require me to already understand it.

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tane_welly
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Sep 15, 2024 at 7:22 PM#13
LipidDoc_ATL said:
Relative and absolute effects need reading together.

Pushing back on LipidDoc_ATL here. I would add the less popular caveat: these trial populations under-represented several groups, older adults and the highest BMI categories among them. The results probably generalise, and "probably" should be stated as an assumption rather than dropped.

Last edited: Sep 15, 2024 at 10:22 PM
25 23DanielChem_CHI, marco_milano, pam_columbus and 22 others
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TirzTom
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Sep 15, 2024 at 10:17 PM#14

Adding the numbers, since they settle part of this. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

Worth separating that from the trial evidence, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

I would rather be corrected than agreed with, if it comes to it.

Last edited: Sep 16, 2024 at 2:17 AM
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mike_mod
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Sep 16, 2024 at 1:12 AM#15

Moderator note: the sourcing question belongs in the vendor section and has been split out. Thread quality here is what the rules are for. Keep it up.

Last edited: Sep 16, 2024 at 3:12 AM
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