From the other side of the consultation, briefly. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.
Correct me if the detail matters more than I have assumed.
jim_asheville said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
This matches mine closely enough to be worth saying so out loud. The detail I would add is minor and it is already implied above.
jim_asheville said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
Coming at jim_asheville’s question from a different direction. The gap between trial results and real-world results is consistent and it is not fraud. Trial participants get titration by protocol, scheduled contact, free drug and dietetic support; removing that infrastructure costs a few percentage points every time it has been measured. When your own curve sits below the published mean, that is the likeliest explanation before anything about you or your material.
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View ResultsThe figures, for anyone assembling their own picture. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.
OP back with an update, since a thread like this is useless without one.
Follow-up: I read the paper rather than the summary and the qualifier I was missing was in the second paragraph of the results.