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ForumsPublic SquareMuscle protein synthesis rates on GLP-1 — leucine threshold discussion Page 4

Muscle protein synthesis rates on GLP-1 — leucine threshold discussion

ChrisMacros Mon, May 25, 2026 at 8:37 AM 21 replies 460 viewsPage 4 of 5
PharmacoVig_BOS
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May 28, 2026 at 6:21 AM#16

Adding the clinical framing, because it changes how the question reads. Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the correction. That is slower than asserting, and it is the only version that survives being wrong.

47 20amsterdam_pete, LondonLisa, mike_nyc and 44 others
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josh_phd_bmore
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May 28, 2026 at 5:06 PM#17
Dr.PathRoch said:
Say what you would expect to see if you were wrong, before you look.

True, and it depends on a baseline nobody has stated. Without knowing where someone started, the same number can be an excellent result or a disappointing one.

Last edited: May 28, 2026 at 7:06 PM
48 21Dr.ObesityLA, NurseKim_ATL, paul_denver and 45 others
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Dr.ObesityMed
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May 29, 2026 at 3:52 AM#18
Dr.PathRoch said:
Say what you would expect to see if you were wrong, before you look.

Thank you — that is the clearest version of this I have read, and I have read a lot of them. Printing the relevant bit and taking it with me.

49 22SurmountFan_IN, PeptideChemSF, A1cHero_PHX and 46 others
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CarlaRPh_TPA
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May 29, 2026 at 2:39 PM#19

Clinical perspective, offered as context rather than as advice. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

50 23labquiet_amy, emily_PDX, Dr.SleepRoch and 47 others
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mike_mod
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May 30, 2026 at 1:25 AM#20

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part.

22 20PurityPaulOR, MaxMetOK, MounjBrad and 19 others
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