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ForumsPharmacology & MechanismsStructure-function of tirzepatide — 12 month update Page 5

Structure-function of tirzepatide — 12 month update

RunnerRach Thu, May 30, 2024 at 1:05 AM 50 replies 2,566 viewsPage 5 of 10
SandraNC_45
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Jun 3, 2024 at 1:43 PM#21
maya_sedona said:
That is right, and it stops being right at the edges.

Can confirm. Same sequence, different timescale. I had assumed I was the exception until I read this.

20 18FranDenver, Dr.BariatricHTX, LindaRN_retired and 17 others
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VendorMark
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Jun 4, 2024 at 5:24 PM#22
maya_sedona said:
That is right, and it stops being right at the edges.

There is a second half to this that has not been said yet. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.

Happy to go further on any of that.

21 19KristenIndy, MarkLI_maint, Dr.PeteFamMed and 18 others
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PeptideSynthNJ
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Jun 5, 2024 at 9:04 PM#23

The figures, for anyone assembling their own picture. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

22 20BenResearch_OR, MikeKY_noInsulin, Dr.RaviCardio and 19 others
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GraceAZ_72
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Jun 7, 2024 at 12:43 AM#24

One thing that is still open after maya_sedona’s answer:

Did your prescriber agree with that reading, and if not what was their objection?

23 21JenPlateau, SallyK_inj, CryptoCarl and 20 others
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MariaRD
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Jun 8, 2024 at 4:22 AM#25
PeptideSynthNJ said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

I read this differently from PeptideSynthNJ, on substance rather than tone. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

24 22nancy_portland, rick_sfbay, maria_elpaso and 21 others
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