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ForumsPharmacology & MechanismsStructure-function of tirzepatide — 12 month update Page 4

Structure-function of tirzepatide — 12 month update

RunnerRach Thu, May 30, 2024 at 1:05 AM 50 replies 2,566 viewsPage 4 of 10
PharmacoVig_BOS
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Jun 1, 2024 at 10:27 PM#16

From the other side of the consultation, briefly. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

44 17amsterdam_pete, LondonLisa, mike_nyc and 41 others
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LindaRN_retired
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Jun 2, 2024 at 6:19 AM#17
PharmacoVig_BOS said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.

That is the short version; the long version is somebody else's post.

Last edited: Jun 2, 2024 at 9:19 AM
45 18Dr.GutHealth, amsterdam_pete, LondonLisa and 42 others
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maya_sedona
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Jun 2, 2024 at 2:11 PM#18
PharmacoVig_BOS said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.

46 19BenResearch_OR, MikeKY_noInsulin, Dr.RaviCardio and 43 others
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LondonLisa
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Jun 2, 2024 at 10:03 PM#19
PharmacoVig_BOS said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Saving this. It is the first explanation that did not require me to already understand it. I will report back once I have actually tried it.

47 20JenPlateau, SallyK_inj, CryptoCarl and 44 others
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mike_mod
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Jun 3, 2024 at 5:55 AM#20

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. No action needed from anybody.

19 17PurityPaulOR, MaxMetOK, MounjBrad and 16 others
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