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ForumsPharmacology & MechanismsStructure-activity relationships of GLP-1 analogs — anyone have experience? Page 7

Structure-activity relationships of GLP-1 analogs — anyone have experience?

sarah_TO Wed, Oct 30, 2024 at 10:31 PM 32 replies 1,968 viewsPage 7 of 7
LabKate
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Nov 29, 2024 at 3:36 AM#31

One thing that is still open after sean_dublin’s answer:

What did you change at the same time, and can you separate the two now?

18 16JenMemphis, pat_auckland, Dr.GastroMayo and 15 others
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Dr.ReproEndo
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Dec 1, 2024 at 2:50 AM#32
sarah_TO said:
Update — tachyphylaxis to the gastric effect, persistence of the appetite effect.

This is where I part company with the consensus forming above. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

Last edited: Dec 1, 2024 at 3:50 AM
19 17andrew_nyc, Dr.EndoEP, GraceAZ_72 and 16 others
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FranDenver
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Dec 3, 2024 at 2:03 AM#33
sarah_TO said:
Update — tachyphylaxis to the gastric effect, persistence of the appetite effect.

No disagreement with sarah_TO. One condition attached. Yes, and the corollary is less popular: if the reasoning holds, it also holds where it produces an answer we do not like.

20 18BariatricNurseD, MASHdoc_SA, GenomicsKate and 17 others
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stefan_berlin
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Dec 5, 2024 at 1:15 AM#34
sarah_TO said:
Update — tachyphylaxis to the gastric effect, persistence of the appetite effect.

This answered a question I did not know how to ask. Printing the relevant bit and taking it with me.

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Dr.RheumBOS
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Dec 7, 2024 at 12:26 AM#35

From the other side of the consultation, briefly. Take it one variable at a time. Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent argument can untangle them after the fact.

Last edited: Dec 7, 2024 at 6:26 AM
22 20Dr.PulmRoch, maya_sedona, stefan_berlin and 19 others
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