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ForumsPharmacology & MechanismsHas anyone dealt with molecular dynamics simulations of glp-1r binding? Page 6

Has anyone dealt with molecular dynamics simulations of glp-1r binding?

BrianDallas92 Wed, Apr 16, 2025 at 2:37 AM 36 replies 1,942 viewsPage 6 of 8
TirzTom
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Jul 18, 2025 at 2:02 AM#26

One concrete data point for the thread. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

That is the short version; the long version is somebody else's post.

26 24josh_phd_bmore, roxy_nash, tony_orlando and 23 others
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TinaHashiRN
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Jul 30, 2025 at 11:49 AM#27

A narrower follow-up, since the general answer is now clear:

Did your prescriber agree with that reading, and if not what was their objection?

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paige_pharma
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Aug 11, 2025 at 9:29 PM#28
TirzTom said:
For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Pushing back on the consensus forming here. Consistency is not the same as correctness, and a board that agrees with itself quickly is usually agreeing with the first person who sounded certain.

Last edited: Aug 11, 2025 at 10:29 PM
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greg_boulder
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Aug 24, 2025 at 7:01 AM#29
TirzTom said:
For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

Agreed, and one caution: a single measurement is not a measurement. Anything that moves day to day needs a trend before it means anything at all.

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BrianDallas92
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Sep 5, 2025 at 4:26 PM#30

OP back with an update, since a thread like this is useless without one.

Update — tachyphylaxis to the gastric effect, persistence of the appetite effect. Two curves, and I had been watching the wrong one.

1 24GraceAZ_72
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