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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsHas anyone dealt with molecular dynamics simulations of glp-1r binding? Page 5

Has anyone dealt with molecular dynamics simulations of glp-1r binding?

BrianDallas92 Wed, Apr 16, 2025 at 2:37 AM 36 replies 1,942 viewsPage 5 of 8
KevinCompounds
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May 16, 2025 at 11:20 PM#21
PharmacoVig_BOS said:
One practical note: write down what you did and when, before you need it.

No disagreement, though the timescale matters more than the mechanism here. Most of what looks like a difference in kind turns out to be a difference in how long somebody waited.

21 19jennifer_SEA, tyler_CSCS, VanRx_Mike and 18 others
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lisa_labSD
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May 29, 2025 at 9:43 AM#22
PharmacoVig_BOS said:
One practical note: write down what you did and when, before you need it.

Genuinely useful, thank you. I had the facts and not the framework. Taking it to my next appointment.

Last edited: May 29, 2025 at 12:43 PM
22 20maya_sedona, stefan_berlin, Dr.EM_Chicago and 19 others
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jim_asheville
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Jun 10, 2025 at 7:59 PM#23

From the other side of the consultation, briefly. Start from the measurement rather than the conclusion. Almost every disagreement here turns out to be two people measuring different things and comparing the numbers anyway.

23 21NurseAsh_DET, BenResearch_OR, MikeKY_noInsulin and 20 others
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FitDadDave
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Jun 23, 2025 at 6:07 AM#24
jim_asheville said:
Start from the measurement rather than the conclusion.

Can confirm. Same sequence, different timescale. The detail I would add is minor and it is already implied above.

24 22wendy_avl, jason_paloalto, Dr.LeslieOBGYN and 21 others
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Dr.RenalNash
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Jul 5, 2025 at 4:08 PM#25
jim_asheville said:
Start from the measurement rather than the conclusion.

Coming at jim_asheville’s question from a different direction. It helps to ask what evidence would change your mind before you look at any. If nothing would, the discussion is not about evidence, and it is better to say so early than to spend nine posts discovering it.

Last edited: Jul 5, 2025 at 9:08 PM
25 23maria_elpaso, anders_CPH, Dr.NutriCornell and 22 others
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