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ForumsPharmacology & MechanismsReceptor internalization and recycling — anyone have experience? Page 4

Receptor internalization and recycling — anyone have experience?

jennifer_SEA Sat, Apr 26, 2025 at 6:12 AM 36 replies 2,034 viewsPage 4 of 8
sophie_paris
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Apr 28, 2025 at 7:26 AM#16

Adding the clinical framing, because it changes how the question reads. Take it one variable at a time. Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent argument can untangle them after the fact.

Last edited: Apr 28, 2025 at 12:26 PM
11 9SallyK_inj, CryptoCarl, MariaRD and 8 others
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Dr.ObesityLA
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Apr 28, 2025 at 2:49 PM#17
NicoleRaleigh said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

True, with the qualification that this is a self-selected group. The people for whom it did not work post less, and that shapes everything we think we know.

Last edited: Apr 28, 2025 at 3:49 PM
12 10KarenAZ_mom, zoe_NC, Dr.ObesityLA and 9 others
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ingrid_STO
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Apr 28, 2025 at 10:12 PM#18
NicoleRaleigh said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

This answered a question I did not know how to ask. I will report back once I have actually tried it.

13 11MikeFit_NJ, InsuranceTom, WendyG_ATL and 10 others
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pete_nash
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Apr 29, 2025 at 5:35 AM#19

Clinical perspective, offered as context rather than as advice. Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the correction. That is slower than asserting, and it is the only version that survives being wrong.

14 12SarahChen_PharmD, sarah.morrison, NeuroNate and 11 others
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Admin
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Apr 29, 2025 at 12:58 PM#20

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Tagging this one for the weekly digest.

Last edited: Apr 29, 2025 at 4:58 PM
36 9PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 33 others
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