Oops I think I injected into muscle - panicking — need advice

Dr.EM_Chicago said:

Bone density monitoring on lean mass: DEXA bone density at baseline and month 12.

Regarding lean mass: I accidentally injected my dose intramuscularly instead of subcutaneously last week (went in at wrong angle, too deep). Called my pharmacist — they said it's not dangerous but may absorb faster, potentially causing more GI effects.

Sure enough, had worse nausea that day. Lesson learned: pinch the skin properly and use the right needle length for your body composition.

Dr.EndoEP said:

Agreed on the ranges, with the condition that a single DEXA is not a measurement, it is one draw from a distribution.

Thank you — that is the clearest version of this I have read, and I have read a lot of them. Printing the relevant bit and taking it with me.

Dr.EM_Chicago said:

Bone density monitoring on lean mass: DEXA bone density at baseline and month 12.

Sharing my comprehensive lab data relevant to lean mass:

Protocol: Tirzepatide 15mg/wk, resistance training 4x/week, protein 1.6g/kg/day.

The improvements in lean mass are clearly reflected in these numbers. The inflammatory marker reduction (hsCRP) is particularly striking.

sarah_TO said:

Two DEXA scans eleven months apart: down 24kg total, of which the scan says 6kg was lean.

Physical therapist weighing in on lean mass. I work with bariatric and metabolic patients daily.

The resistance training evidence is critical here:

The Lundgren 2024 JAMA paper[1] showed that structured resistance training preserved 73% more lean mass in GLP-1 patients vs medication alone. When discussing lean mass, we MUST include the exercise component.

My minimum prescription: 3x/week compound movements (squat, deadlift, press, row), progressive overload, 7-10K steps/day, and 1.2-1.6g protein/kg/day.

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