Steady-state concentrations across dose tiers — January 2024

Dr.DermMIA said:

Peptide calculator app recommendation for dosing arithmetic: I use PeptideCalc to calculate reconstitution volumes and injection doses.

Ongoing cost tracking for dosing arithmetic — transparency for the community:

Monthly medication cost: $125
Supplies (syringes, BAC water, alcohol swabs): ~$8/month
Janoshik testing: ~$10/month (amortized quarterly)
Lab work: ~$45/month (amortized quarterly)
Total: ~$195/month

Compare to brand Wegovy at $1365/month without insurance. Compounded is roughly 90% cheaper for what I have found to be clinically equivalent medication.

CanadaChris said:

Agreed, and it is worth saying that rounding to the nearest whole unit is usually acceptable at maintenance doses and is not acceptable at the bottom…

Thank you for spelling out the reasoning rather than just the conclusion. Adding it to my notes with a link back to this thread.

Dr.DermMIA said:

Peptide calculator app recommendation for dosing arithmetic: I use PeptideCalc to calculate reconstitution volumes and injection doses.

Quick syringe math for dosing arithmetic dosing: if your vial is reconstituted at 5mg/2mL, that's 2.5mg/mL. For a 0.25mg dose you need 0.1mL = 10 units on an insulin syringe.

I keep a chart on my fridge:

• 0.25mg = 10 units
• 0.5mg = 20 units
• 1.0mg = 40 units
• 1.25mg = 50 units

Always double-check your concentration before drawing up!

Dr.GastroMayo said:

I reconstituted a 10mg vial with 2ml of bacteriostatic water and I want someone to check my unit arithmetic before I draw anything, because I keep…

Just received my dosing arithmetic order — packaging review:

• Outer box: plain brown, no medication identifiers (discreet) ✅
• Inner insulation: Styrofoam with 4 gel ice packs ✅
• Temperature: vials were cold to touch on arrival ✅
• Labeling: lot number, BUD, compound name, concentration ✅
• Included: COA, reconstitution instructions, dosing card ✅

This is what professional compounding pharmacy shipping looks like. If your order arrives without these basics, reconsider your vendor.

Moderator note: the sourcing question belongs in the vendor section and has been split out. Tagging this one for the weekly digest.