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ForumsDosing & ProtocolsInsulin syringe unit conversion for compounded sema — 12 month update Page 6

Insulin syringe unit conversion for compounded sema — 12 month update

BrianDallas92 Tue, Dec 17, 2024 at 3:18 AM 34 replies 1,924 viewsPage 6 of 7
mark_tokyo
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Feb 24, 2025 at 11:33 PM#26
DataDave said:
Reconstitution tip for anyone mixing dosing arithmetic from lyophilized powder: use bacteriostatic water, NOT sterile water.

Compounding pharmacy dose accuracy check for dosing arithmetic: I always verify my first dose from a new vial by weighing it on a milligram scale. Draw up your dose, weigh the syringe, subtract empty syringe weight, compare to expected water weight at that volume.

For a 10-unit dose (0.1mL): expected weight ~100mg of water. If it's significantly off, your syringe may be inaccurate. Cheap insulin syringes can have ±5% volume accuracy. Spring for quality brands like BD or Terumo.

Last edited: Feb 25, 2025 at 2:33 AM
27 0pete_manc_UK, anna.melb_AU, mark_tokyo and 24 others
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WendyG_ATL
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Mar 6, 2025 at 6:30 AM#27
DataDave said:
Reconstitution tip for anyone mixing dosing arithmetic from lyophilized powder: use bacteriostatic water, NOT sterile water.

This is exactly what I could not find anywhere else. Printing the relevant bit and taking it with me.

28 1rachel_ABQ, traveltech_sara, AttorneyGrant and 25 others
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PeptideChemSF
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Mar 15, 2025 at 1:21 PM#28

From the other side of the consultation, briefly.

Comparison of compounded dosing arithmetic delivery formats I've tried:

FormatProsCons
Lyophilized vialLongest shelf life, lowest costRequires reconstitution
Pre-mixed vialReady to draw upShorter shelf life (28-45 days)
Pre-filled syringesMost convenientHigher cost, shorter shelf life
Sublingual dropsNo needlesLower bioavailability, less data

I use lyophilized vials for cost and stability. The reconstitution takes 30 seconds once you've done it a few times.

Last edited: Mar 15, 2025 at 5:21 PM
29 2FDA_TrackerJim, ricardo_MIA, BrianDallas92 and 26 others
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andrew_nyc
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Mar 24, 2025 at 8:07 PM#29
PeptideChemSF said:
Comparison of compounded dosing arithmetic delivery formats I've tried: Format Pros Cons Lyophilized vial Longest shelf life, lowest cost Requires…

Mine went the same way, slower. I had assumed I was the exception until I read this.

30 3julia.endo, JessicaM_2024, TomFromTexas and 27 others
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BrianDallas92
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Apr 3, 2025 at 2:48 AM#30

Reporting back.

The bulks-list asymmetry was the piece I had missed entirely. It explains why one of my two pharmacies is still arguing it can supply and the other simply stopped.

Last edited: Apr 3, 2025 at 3:48 AM
2 0GraceAZ_72, carl_compliance
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