Oops I think I injected into muscle - panicking — what worked for you?

PharmHunterJen said:

SarahChen_PharmD said: ...the muscle loss concern with lean mass...

Bone density monitoring on lean mass: DEXA bone density at baseline and month 12.

Lumbar spine T-score: -0.8 → -0.9 (stable to slightly improved)
Femoral neck T-score: -0.10 → -0.10 (stable)

No significant bone loss despite 75 lbs of weight loss. Key factors: adequate calcium (1200mg/day), vitamin D (5000 IU/day), resistance training 3x/week, and adequate protein. Weight-bearing exercise is critical for maintaining bone density during rapid weight loss.

julia.endo said:

Right, and protein targets should be set on a reference weight rather than current weight.

Thank you — that is the clearest version of this I have read, and I have read a lot of them.

PharmHunterJen said:

SarahChen_PharmD said: ...the muscle loss concern with lean mass...

Physical therapist weighing in on lean mass. I work with bariatric and metabolic patients daily.

The resistance training evidence is critical here:

The Lundgren 2024 JAMA paper[1] showed that structured resistance training preserved 73% more lean mass in GLP-1 patients vs medication alone. When discussing lean mass, we MUST include the exercise component.

My minimum prescription: 3x/week compound movements (squat, deadlift, press, row), progressive overload, 7-10K steps/day, and 1.2-1.6g protein/kg/day.

amsterdam_pete said:

I lifted three times a week throughout and still lost lean mass.

OMG yes. lean mass + resistance training is the combo. Can confirm.

Moderator note: the sourcing question belongs in the vendor section and has been split out. Report rather than reply if it drifts again.