Semaglutide 1.0mg for maintenance — 12 month update

PharmD_Rodriguez said:

The distinction that resolves most of these threads is between what is true on average and what is true for one person.

Adding the part of the answer the thread has not reached. Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak. People who dose late are not losing a peak, they are letting the trough fall, and the appetite effect tracks the trough.

The figures, for anyone assembling their own picture. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

Following on from PharmD_Rodriguez — and this may be the naive question:

How much of the between-person variation is pharmacokinetic and how much is just adherence measured badly?

BiostatsBrad said:

Worth stating the units and the reference range whenever you post a number here.

I read this differently from BiostatsBrad, on substance rather than tone. The counter-case has not been addressed. Somebody upthread described the situation that does not fit, and the thread moved on rather than engaging with it, which is the failure mode this board is supposed to avoid.

BiostatsBrad said:

Worth stating the units and the reference range whenever you post a number here.

That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.