sarah.morrison said:Dead space is the answer to the missing dose.
I am going to disagree with reconstituting low as a general rule. More diluent, more punctures, more in-use days at room temperature, and the stability trade-off is real. Precision is not the only variable being optimised.
If somebody has the primary source to hand I would rather cite it than paraphrase it.
The figures, for anyone assembling their own picture. Red flags, in rough order of how much they should worry you: no verifiable address, no batch numbers, prices far under market, vendor-commissioned tests only, pressure toward irreversible payment, and shipping with no temperature control.
mike_nyc said:I am going to disagree with reconstituting low as a general rule.
There is a second half to this that has not been said yet. Prices dramatically below market are the strongest single signal, and the reason is arithmetic rather than suspicion. Synthesis, testing, and cold-chain shipping have floors. A price well under the floor means something was skipped, and the two things that get skipped are testing and content.
Worth separating that from vendor vetting, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.
Correct me if the detail matters more than I have assumed.
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Browse GL BiochemA narrower follow-up, since the general answer is now clear:
How much material I am losing to dead space, and whether that explains why a 10mg vial gives me nine usable draws rather than ten?
Reporting back.
Resolved. I wrote mg, ml and mg/ml on the vial in marker and did the division in that order, and the two of us now get the same number every time.