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ForumsPharmacology & MechanismsGLP-1R allosteric modulators — future of non-peptide agonists Page 3

GLP-1R allosteric modulators — future of non-peptide agonists

PeptideChemSF Tue, May 26, 2026 at 8:01 PM 12 replies 473 viewsPage 3 of 3
JenPlateau
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May 27, 2026 at 11:24 PM#11
andrew_nyc said:
The manufacturing argument is the underrated one.

Thank you — that is the clearest version of this I have read, and I have read a lot of them. Taking it to my next appointment.

46 19HPLC_Greg, LibrarianMeg, bri_stats and 43 others
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Dr.LeslieOBGYN
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May 28, 2026 at 8:11 AM#12

Adding the clinical framing, because it changes how the question reads. The useful move here is to separate what is established from what is widely repeated. Those two sets overlap less than the confident tone of most write-ups suggests, and the second set is where nearly all the disagreement on this board comes from.

Last edited: May 28, 2026 at 2:11 PM
47 20FranDenver, Dr.BariatricHTX, LindaRN_retired and 44 others
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Dr.MetabolicMD
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May 28, 2026 at 4:58 PM#13
Dr.BariatricHTX said:
The mechanism and the magnitude are separate questions.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.

48 21HealthEcon_DC, PedsEndoPhilly, SleepDoc_PDX and 45 others
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VendorMark
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May 29, 2026 at 1:45 AM#14

One concrete data point for the thread. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.

49 22Dr.PeteFamMed, claudia_zurich, nancy_portland and 46 others
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mike_mod
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May 29, 2026 at 10:32 AM#15

Moderator note: a couple of off-topic posts removed.

Last edited: May 29, 2026 at 12:32 PM
50 23PurityPaulOR, MaxMetOK, MounjBrad and 47 others
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