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ForumsPharmacology & MechanismsGLP-1R allosteric modulators — future of non-peptide agonists Page 2

GLP-1R allosteric modulators — future of non-peptide agonists

PeptideChemSF Tue, May 26, 2026 at 8:01 PM 12 replies 473 viewsPage 2 of 3
TirzTom
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May 27, 2026 at 12:36 AM#6

Adding the numbers, since they settle part of this. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

Last edited: May 27, 2026 at 4:36 AM
8 3josh_phd_bmore, roxy_nash, tony_orlando and 5 others
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tane_welly
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May 27, 2026 at 2:24 AM#7

One thing that is still open after andrew_nyc’s answer:

What did you change at the same time, and can you separate the two now?

7 2carl_compliance, DanielChem_CHI, marco_milano and 4 others
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Dr.BariatricHTX
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May 27, 2026 at 4:12 AM#8
TirzTom said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

Coming at TirzTom’s question from a different direction. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

6 1Dr.EM_Chicago, pete_RVA, CarlaRPh_TPA and 3 others
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PeptideChemSF
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May 27, 2026 at 6:00 AM#9

Reporting back.

Coming back a few months on. It held. Nothing dramatic to report, which is the report.

5 0ricardo_MIA, BrianDallas92, labquiet_amy and 2 others
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Dr.GastroMayo
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May 27, 2026 at 2:37 PM#10
Dr.BariatricHTX said:
The mechanism and the magnitude are separate questions.

Correct, and worth adding that it is reversible. Nothing being described here is a one-way door, which changes how cautious it is reasonable to be.

Last edited: May 27, 2026 at 7:37 PM
45 18InsuranceTom, WendyG_ATL, SaraMom3 and 42 others
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