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ForumsDosing & ProtocolsHas anyone dealt with dose escalation too fast? recognizing over-titration symptoms? Page 3

Has anyone dealt with dose escalation too fast? recognizing over-titration symptoms?

traveltech_sara Sat, Mar 28, 2026 at 7:33 PM 26 replies 774 viewsPage 3 of 6
kevin_tulsa
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Mar 29, 2026 at 3:41 PM#11
hans_munich said:
A step that is uncomfortable at week two is frequently comfortable at week six with no change in dose, because the gastric-emptying component…

Thank you for spelling out the reasoning rather than just the conclusion. Printing the relevant bit and taking it with me.

26 24fiona_glasgow, Dr.RheumBOS, greg_boulder and 23 others
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Dr.LeslieOBGYN
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Mar 29, 2026 at 7:46 PM#12

From the other side of the consultation, briefly. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

27 0FranDenver, Dr.BariatricHTX, LindaRN_retired and 24 others
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Dr.BariatricHTX
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Mar 29, 2026 at 11:51 PM#13
NurseKim_ATL said:
PSA for titration users considering the 0.25mg starting dose: this dose is NOT intended for weight loss.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.

28 1Dr.EM_Chicago, pete_RVA, CarlaRPh_TPA and 25 others
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PeptideChemSF
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Mar 30, 2026 at 3:55 AM#14

Adding the numbers, since they settle part of this. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.

29 2ricardo_MIA, BrianDallas92, labquiet_amy and 26 others
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Admin
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Mar 30, 2026 at 7:59 AM#15

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Thread quality here is what the rules are for. Keep it up.

30 3PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 27 others
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