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ForumsDosing & ProtocolsInsulin syringe units to mg conversion — the complete reference thread Page 5

Insulin syringe units to mg conversion — the complete reference thread

PharmD_Rodriguez Mon, Feb 12, 2024 at 6:40 PM 530 replies 54,976 viewsPage 5 of 20
MASHdoc_SA
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Mar 6, 2024 at 3:48 PM#21
SleepDoc_PDX said:
Sharing my dosing arithmetic titration experience with compounded semaglutide — I have been tracking injection volumes meticulously: Using 5mg/2mL…

Compounding pharmacy dose accuracy check for dosing arithmetic: I always verify my first dose from a new vial by weighing it on a milligram scale. Draw up your dose, weigh the syringe, subtract empty syringe weight, compare to expected water weight at that volume.

For a 10-unit dose (0.1mL): expected weight ~100mg of water. If it's significantly off, your syringe may be inaccurate. Cheap insulin syringes can have ±5% volume accuracy. Spring for quality brands like BD or Terumo.

25 23TirzTom, TrialTracker_MD, JennaRN and 22 others
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Dr.ObesityMed
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Mar 15, 2024 at 3:20 PM#22
SleepDoc_PDX said:
Sharing my dosing arithmetic titration experience with compounded semaglutide — I have been tracking injection volumes meticulously: Using 5mg/2mL…

Bookmarking. The distinction being drawn above is the one nobody else makes. Printing the relevant bit and taking it with me.

26 24PharmacoVig_BOS, SurmountFan_IN, PeptideChemSF and 23 others
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pete_nash
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Mar 24, 2024 at 2:47 PM#23

Adding the clinical framing, because it changes how the question reads.

Comparison of compounded dosing arithmetic delivery formats I've tried:

FormatProsCons
Lyophilized vialLongest shelf life, lowest costRequires reconstitution
Pre-mixed vialReady to draw upShorter shelf life (28-45 days)
Pre-filled syringesMost convenientHigher cost, shorter shelf life
Sublingual dropsNo needlesLower bioavailability, less data

I use lyophilized vials for cost and stability. The reconstitution takes 30 seconds once you've done it a few times.

27 0mike_mod, SarahChen_PharmD, sarah.morrison and 24 others
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paige_pharma
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Apr 2, 2024 at 2:09 PM#24
pete_nash said:
Comparison of compounded dosing arithmetic delivery formats I've tried: Format Pros Cons Lyophilized vial Longest shelf life, lowest cost Requires…

Second this.

28 1lisa_labSD, adam_van, Dr.SurgeonPGH and 25 others
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RegAffairsDC
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Apr 11, 2024 at 1:25 PM#25
pete_nash said:
Comparison of compounded dosing arithmetic delivery formats I've tried: Format Pros Cons Lyophilized vial Longest shelf life, lowest cost Requires…

For anyone reconstituting dosing arithmetic peptides: the water-to-powder ratio determines your concentration. Here's my reference:

Vial SizeBAC WaterConcentration0.25mg Dose
5mg2mL2.5mg/mL10 units
5mg2.5mL2mg/mL12.5 units
10mg2mL5mg/mL5 units
10mg3mL3.33mg/mL7.5 units

More water = easier to measure small doses but vial runs out faster. Find the balance that works for your dose.

Last edited: Apr 11, 2024 at 3:25 PM
29 2gary_naperville, sean_dublin, hannah_MT and 26 others
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