My problem is day one and day two, not the week as a whole, which is why splitting appealed to me before I read anything about it.
What I am trying to establish is what the pharmacokinetic argument against splitting a weekly dose actually is, since intuitively it should smooth the curve.
Not looking for reassurance. Looking for the part I have got wrong.
Short answer first, then the reasoning. Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak. People who dose late are not losing a peak, they are letting the trough fall, and the appetite effect tracks the trough.
LibrarianMeg said:Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak.
Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.
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Shop Reference StandardsDr.ObesityMed said:My problem is day one and day two, not the week as a whole, which is why splitting appealed to me before I read anything about it.
That holds for the injectable. The oral formulation has different absorption behaviour and the dose numbers are not interchangeable, which is worth saying out loud because people quote them as if they were.
Clinical perspective, offered as context rather than as advice.
Dose splitting update on split dosing: instead of 2.4mg once weekly, I've been doing 1.2mg twice weekly (Mon/Thu) with my doctor's approval. The appetite suppression is more consistent and side effects are noticeably milder.
Not medical advice, just sharing what's worked for me. Discuss with your provider before trying this.