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ForumsDosing & ProtocolsSemaglutide titration: 0.25→0.5→1.0→1.7→2.4mg optimal schedule Page 17

Semaglutide titration: 0.25→0.5→1.0→1.7→2.4mg optimal schedule

Dr.Martinez Mon, Feb 26, 2024 at 4:00 PM 332 replies 13,278 viewsPage 17 of 20
Dr.Martinez
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Mar 31, 2024 at 7:03 AM#81

OP back with an update, since a thread like this is useless without one.

Closing this out: I held the step for six weeks rather than four and it settled without a dose change. The interval was the answer, not the dose.

3 3AttorneyGrant, DebRD_ATL, KristenIndy
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CanadaChris
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Mar 31, 2024 at 6:57 PM#82
Dr.Martinez said:
Closing this out: I held the step for six weeks rather than four and it settled without a dose change.

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

2 2stefan_berlin, Dr.EM_Chicago
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claudia_zurich
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Apr 1, 2024 at 6:51 AM#83
Dr.Martinez said:
Closing this out: I held the step for six weeks rather than four and it settled without a dose change.

No disagreement, though the timescale matters more than the mechanism here. Most of what looks like a difference in kind turns out to be a difference in how long somebody waited.

Last edited: Apr 1, 2024 at 12:51 PM
1 1Dr.LipidDallas
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Dr.KarenChen
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Apr 1, 2024 at 6:44 PM#84
Dr.Martinez said:
Closing this out: I held the step for six weeks rather than four and it settled without a dose change.

Saving this. It is the first explanation that did not require me to already understand it.

50 0mike.trainer_LA, sarah_nash92, FitDadDave and 47 others
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newstart_MO
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Apr 2, 2024 at 6:37 AM#85

From the other side of the consultation, briefly. Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third retelling.

49 24RunnerRach, TrialNerd_Beth, HPLC_Greg and 46 others
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