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Evidence-based GLP-1 & peptide discussion since 2023
ForumsNutrition & SupplementationHas anyone dealt with plant-based protein sources for vegan glp-1 users?

Has anyone dealt with plant-based protein sources for vegan glp-1 users?

InsuranceTom Thu, Feb 22, 2024 at 6:30 PM 10 replies 2,173 viewsPage 1 of 2
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InsuranceTom
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Feb 22, 2024 at 6:30 PM#1

My appetite is suppressed enough that hitting a protein target is now the hardest part of the day, and everything I read assumes I can simply eat more.

The narrow version of the question is how people are hitting a protein target on a genuinely suppressed appetite, because volume is the binding constraint rather than willingness.

I would rather have one careful answer than five confident ones.

15 10lisa_labSD, adam_van, Dr.SurgeonPGH and 12 others
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Dr.AddMedPHL
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Feb 22, 2024 at 6:45 PM#2

Answering the narrow version, because the broad one does not have a single answer. The RDA is the wrong reference and it is worth understanding why. 0.8 g/kg is the intake at which nitrogen balance is not negative in healthy weight-stable adults — a floor for deficiency prevention, not an optimum, and derived in a population that is not in a deficit. In a substantial energy deficit, protein requirement rises because amino acids are being oxidised for energy and because muscle protein synthesis is blunted. The literature on preserving lean mass during weight loss lands around 1.4 to 2.0 g/kg of reference body weight, which is roughly two to two and a half times the RDA.

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LabKate
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Feb 22, 2024 at 7:00 PM#3
Dr.AddMedPHL said:
The RDA is the wrong reference and it is worth understanding why.

Agreed on the target, with the caveat that reference weight and current weight are different numbers. Using current weight at the start of a large loss produces a target that is both unachievable and unnecessary.

13 8Dr.SleepRoch, laura_annarbor, JenMemphis and 10 others
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maria_elpaso
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Feb 22, 2024 at 7:15 PM#4
InsuranceTom said:
My appetite is suppressed enough that hitting a protein target is now the hardest part of the day, and everything I read assumes I can simply eat…

This matches mine closely enough to be worth saying so. Distribution matters less than total but it is not nothing. Roughly 25 to 40g per sitting with enough leucine to trigger synthesis, three or four times a day, is more effective than the same total in one enormous evening meal — and on a suppressed appetite the enormous evening meal is the one you will not finish anyway.

Last edited: Feb 23, 2024 at 1:15 AM
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Dr.KarenChen
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Feb 22, 2024 at 8:33 PM#5

Adding the clinical framing, because it changes how the question reads.

DEXA scan update relevant to protein intake:

Scanned at months 0, 6, and 12. Here are the body comp numbers:

BaselineMonth 6Month 12
Total mass281 lbs226 lbs208 lbs
Fat mass111 lbs81 lbs43 lbs
Lean mass149 lbs148 lbs155 lbs
Body fat %42%34%22%

Lean mass preserved — actually GAINED 1-2 lbs thanks to progressive overload + 1.5g/kg protein. The protein intake discussion needs to include body comp data, not just scale weight.

Last edited: Feb 23, 2024 at 2:33 AM
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