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ForumsNutrition & SupplementationCollagen peptides for GLP-1 skin elasticity — my results so far

Collagen peptides for GLP-1 skin elasticity — my results so far

gary_naperville Tue, Jul 9, 2024 at 11:15 PM 37 replies 2,284 viewsPage 1 of 8
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gary_naperville
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Jul 9, 2024 at 11:15 PM#1

Posting this because the summary going around does not say what the paper says, and the difference matters for how people here are using it.

On a suppressed appetite the winning strategy is protein density per unit of volume, not per calorie. Isolate powders, Greek yoghurt and cottage cheese, egg whites, lean fish, and tinned tuna all deliver a lot of protein in a small physical volume. Front-load it: appetite is usually least suppressed in the first hours after waking and worst on the day or two after dosing, so get the majority in early in the day and early in the week.

Where I think it is weakest: the population was selected and supported in ways a real cohort is not, so I would read the effect size as a ceiling rather than an expectation.

What I actually want to know is whether the RDA is the wrong reference entirely during rapid weight loss, and what the actual target should be. Not looking for reassurance. Looking for the part I have got wrong.

Note on sourcing:
Figures above are from the primary publication rather than the press summary. If a number here disagrees with one you have, post yours and we will work out which of us is reading a secondary source.
19 14SleepFixSam, PurityPaulOR, MaxMetOK and 16 others
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MikeFit_NJ
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Jul 10, 2024 at 1:36 AM#2
gary_naperville said:
On a suppressed appetite the winning strategy is protein density per unit of volume, not per calorie.

gary_naperville has the substance of this right. The condition it depends on is worth stating. The RDA is the wrong reference and it is worth understanding why. 0.8 g/kg is the intake at which nitrogen balance is not negative in healthy weight-stable adults — a floor for deficiency prevention, not an optimum, and derived in a population that is not in a deficit. In a substantial energy deficit, protein requirement rises because amino acids are being oxidised for energy and because muscle protein synthesis is blunted. The literature on preserving lean mass during weight loss lands around 1.4 to 2.0 g/kg of reference body weight, which is roughly two to two and a half times the RDA.

Last edited: Jul 10, 2024 at 4:36 AM
18 13marcus_mpls, DeniseRN_TPA, SandraNC_45 and 15 others
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KevinCompounds
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Jul 10, 2024 at 3:57 AM#3
gary_naperville said:
On a suppressed appetite the winning strategy is protein density per unit of volume, not per calorie.

I will push back on the powder-first advice. It works and it also trains people out of eating food, and when the drug stops the habits are what remain. Getting protein from meals is slower and holds up better afterwards.

Last edited: Jul 10, 2024 at 5:57 AM
17 12MikeKY_noInsulin, Dr.RaviCardio, jennifer_SEA and 14 others
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sarah_TO
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Jul 10, 2024 at 6:18 AM#4

Taking the question as asked, rather than the general version of it. Distribution matters less than total but it is not nothing. Roughly 25 to 40g per sitting with enough leucine to trigger synthesis, three or four times a day, is more effective than the same total in one enormous evening meal — and on a suppressed appetite the enormous evening meal is the one you will not finish anyway.

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NicoleRaleigh
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Jul 10, 2024 at 8:21 PM#5
MikeFit_NJ said:
The RDA is the wrong reference and it is worth understanding why.

Adding a me-too, because a thread of one person's experience is not much use. Nothing to add that would improve it.

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