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ForumsNutrition & SupplementationCreatine monohydrate + GLP-1 — 12 month update

Creatine monohydrate + GLP-1 — 12 month update

nancy_portland Sun, Aug 18, 2024 at 12:03 AM 13 replies 2,015 viewsPage 1 of 3
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nancy_portland
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Aug 18, 2024 at 12:03 AM#1

Two DEXA scans eleven months apart: down 24kg total, of which the scan says 6kg was lean. I want to know whether that ratio is bad, normal, or simply what happens.

What would genuinely help is knowing what fraction of loss being lean mass is actually normal, because the numbers quoted here range from 10% to 40% and cannot all be right.

Happy to be told the question itself is wrong.

12 7DebRD_ATL, KristenIndy, MarkLI_maint and 9 others
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Dr.LipidDallas
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Aug 18, 2024 at 12:21 AM#2

This one has a reasonably settled answer, so here it is. The intervention that works is boring and well evidenced: resistance training two to three times a week at a genuine effort, protein at 1.4 to 2.0 g/kg of reference body weight, and not making the deficit larger than the training can support. Cardio does not protect lean mass and in a deep deficit competes with recovery.

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Dr.EM_Chicago
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Aug 18, 2024 at 12:39 AM#3
Dr.LipidDallas said:
The intervention that works is boring and well evidenced: resistance training two to three times a week at a genuine effort, protein at 1.4 to 2.0…

Right, and protein targets should be set on a reference weight rather than current weight. Setting 1.6 g/kg on a starting weight of 130kg produces a target nobody hits on a suppressed appetite.

10 5Dr.ReproEndo, lucas_SP_BR, lisa_labSD and 7 others
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greg_boulder
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Aug 18, 2024 at 12:57 AM#4
nancy_portland said:
Two DEXA scans eleven months apart: down 24kg total, of which the scan says 6kg was lean.

This matches mine closely enough to be worth saying so. The honest range is roughly 20 to 40% of total loss as lean mass without deliberate resistance training, and roughly 10 to 20% with it plus adequate protein. Both numbers need a caveat that matters: "lean mass" on a DEXA is not muscle. It includes water, glycogen and the lean fraction of organs, and glycogen alone carries about three grams of water per gram. A large early lean drop is mostly the glycogen and water going, which is why the first scan flatters and the second is the honest one.

Last edited: Aug 18, 2024 at 2:57 AM
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Dr.KarenChen
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Aug 18, 2024 at 2:35 AM#5

Clinical perspective, offered as context rather than as advice.

Body composition tracking via bioimpedance on lean mass (InBody scan every 3 months):

MetricBaselineMonth 3Month 6Month 9
Skeletal Muscle (lbs)69717271
Body Fat (lbs)91755345
Body Fat %39%32%26%21%
Visceral Fat (cm²)1461118156

Note: skeletal muscle mass dipped initially then recovered with consistent resistance training + high protein. The visceral fat reduction is where the metabolic magic happens.

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