Dr.PeteFamMed said:Distribution matters less than total but it is not nothing.
Thank you — that is the clearest version of this I have read, and I have read a lot of them. I will report back once I have actually tried it.
Clinical perspective, offered as context rather than as advice. It helps to say which part of this you are uncertain about. A precise question gets a precise answer; a general one gets everybody’s favourite anecdote.
Dr.PathRoch said:If two explanations both fit, the useful question is which one predicts something the other does not.
Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.
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Browse GL BiochemOne concrete data point for the thread. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.
Correct me if the detail matters more than I have assumed.