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ForumsNutrition & SupplementationPlant-based protein sources for vegan GLP-1 users — my results so far

Plant-based protein sources for vegan GLP-1 users — my results so far

NeuroNate Sat, Jan 3, 2026 at 10:43 PM 30 replies 1,493 viewsPage 1 of 6
NeuroNate
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Jan 3, 2026 at 10:43 PM#1

This gets cited here weekly, usually second-hand, so it is worth setting out what it does and does not establish.

Distribution matters less than total but it is not nothing. Roughly 25 to 40g per sitting with enough leucine to trigger synthesis, three or four times a day, is more effective than the same total in one enormous evening meal — and on a suppressed appetite the enormous evening meal is the one you will not finish anyway.

Where I think it is weakest: the completion rate deserves as much attention as the headline, because a large effect among those who finished is a different claim from a large effect among those enrolled.

The bit I cannot resolve on my own is whether the RDA is the wrong reference entirely during rapid weight loss, and what the actual target should be. I would rather have one careful answer than five confident ones.

Note on sourcing:
Figures above are from the primary publication rather than the press summary. If a number here disagrees with one you have, post yours and we will work out which of us is reading a secondary source.
49 19jason_paloalto, Dr.LeslieOBGYN, MikeNYC_runner and 46 others
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HPLC_Greg
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Jan 3, 2026 at 10:53 PM#2
NeuroNate said:
Distribution matters less than total but it is not nothing.

No disagreement with NeuroNate. One condition attached. On a suppressed appetite the winning strategy is protein density per unit of volume, not per calorie. Isolate powders, Greek yoghurt and cottage cheese, egg whites, lean fish, and tinned tuna all deliver a lot of protein in a small physical volume. Front-load it: appetite is usually least suppressed in the first hours after waking and worst on the day or two after dosing, so get the majority in early in the day and early in the week.

Last edited: Jan 4, 2026 at 4:53 AM
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labquiet_amy
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Jan 3, 2026 at 11:03 PM#3
NeuroNate said:
Distribution matters less than total but it is not nothing.

I will push back on the powder-first advice. It works and it also trains people out of eating food, and when the drug stops the habits are what remain. Getting protein from meals is slower and holds up better afterwards.

Last edited: Jan 4, 2026 at 1:03 AM
47 17LibrarianMeg, bri_stats, pete_manc_UK and 44 others
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roxy_nash
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Jan 3, 2026 at 11:13 PM#4

Taking the question as asked, rather than the general version of it. The RDA is the wrong reference and it is worth understanding why. 0.8 g/kg is the intake at which nitrogen balance is not negative in healthy weight-stable adults — a floor for deficiency prevention, not an optimum, and derived in a population that is not in a deficit. In a substantial energy deficit, protein requirement rises because amino acids are being oxidised for energy and because muscle protein synthesis is blunted. The literature on preserving lean mass during weight loss lands around 1.4 to 2.0 g/kg of reference body weight, which is roughly two to two and a half times the RDA.

46 16Dr.NephBHM_UK, kim_atl_prep, sarah_TO and 43 others
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cory_ATX
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Jan 4, 2026 at 12:06 AM#5
HPLC_Greg said:
On a suppressed appetite the winning strategy is protein density per unit of volume, not per calorie.

Right, and one flattering data point from a group buy is not consistency. Consistency means separate batches, separately commissioned, over months.

Correct me if the detail matters more than I have assumed.

Last edited: Jan 4, 2026 at 2:06 AM
45 15tane_welly, Dr.PathRoch, mona_PHX and 42 others
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