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ForumsCOA & Analytical TestingPaid for independent testing and results did not match vendor COA — looking for input Page 2

Paid for independent testing and results did not match vendor COA — looking for input

PurityPaulOR Wed, Jan 24, 2024 at 4:26 AM 19 replies 2,175 viewsPage 2 of 4
InsuranceTom
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Jan 25, 2024 at 11:32 AM#6
anders_CPH said:
The useful checklist is about verifiability rather than presentation.

I disagree that testing history is decisive. It tells you what a supplier did when they were being watched. Continuity of behaviour under stress — a late shipment, a failed test, a complaint — is more predictive than any run of good results.

18 13lisa_labSD, adam_van, Dr.SurgeonPGH and 15 others
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TirzTom
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Jan 25, 2024 at 11:58 PM#7

Adding the numbers, since they settle part of this. The four things to check on any report, in order: does it name your batch, who commissioned it, what method was used, and does it report content as well as purity. A report failing any of those is weak evidence regardless of the percentage on it.

17 12tom_AK, josh_phd_bmore, roxy_nash and 14 others
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sean_dublin
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Jan 26, 2024 at 12:24 PM#8
InsuranceTom said:
I disagree that testing history is decisive.

Coming at InsuranceTom’s question from a different direction. Inter-laboratory variation comes from real methodological differences, not sloppiness: which reference standard was used and how it was itself calibrated, the gradient and column, the detection wavelength, and where the integration baseline was drawn. A percentage point or two between competent labs is expected. What is not expected is a large gap, and the usual explanation there is that one report is not of the batch in your hand.

Last edited: Jan 26, 2024 at 1:24 PM
16 11gary_naperville, sean_dublin, hannah_MT and 13 others
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oliver_london
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Jan 27, 2024 at 12:50 AM#9

A narrower follow-up, since the general answer is now clear:

How people are distinguishing a supplier having a bad batch from a supplier on the way out?

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PurityPaulOR
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Jan 29, 2024 at 12:34 PM#10

Closing the loop on my own question.

Went back through my own correspondence with an earlier supplier and the warning signs were all there in the replies, weeks before the quality changed. I was reading the product and not the behaviour.

Last edited: Jan 29, 2024 at 3:34 PM
15 13mike_mod, SarahChen_PharmD, sarah.morrison and 12 others
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