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ForumsCOA & Analytical TestingCOA red flag compilation — what worked for you?

COA red flag compilation — what worked for you?

mike_nyc Thu, Mar 21, 2024 at 10:51 PM 36 replies 2,728 viewsPage 1 of 8
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mike_nyc
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Mar 21, 2024 at 10:51 PM#1

Posting this because the summary going around does not say what the paper says, and the difference matters for how people here are using it.

The useful checklist is about verifiability rather than presentation. Independent test results commissioned by buyers rather than by the seller, consistency across multiple batches over time rather than one flattering report, a physical address and a company registration that resolve, batch and lot numbers on the actual labelling, and a shipping practice that matches what the material needs. Everything a good-looking website provides is cheap to fake; none of the items above are.

Where I think it is weakest: the completion rate deserves as much attention as the headline, because a large effect among those who finished is a different claim from a large effect among those enrolled.

What would genuinely help is knowing how people are distinguishing a supplier having a bad batch from a supplier on the way out. I have searched first, so if this is covered somewhere point me at it and I will read it.

Note on sourcing:
Figures above are from the primary publication rather than the press summary. If a number here disagrees with one you have, post yours and we will work out which of us is reading a secondary source.
28 23maya_sedona, stefan_berlin, Dr.EM_Chicago and 25 others
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SarahChen_PharmD
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Mar 21, 2024 at 11:30 PM#2
mike_nyc said:
The useful checklist is about verifiability rather than presentation.

That is correct as far as it goes, and here is where it stops going. Prices dramatically below market are the strongest single signal, and the reason is arithmetic rather than suspicion. Synthesis, testing, and cold-chain shipping have floors. A price well under the floor means something was skipped, and the two things that get skipped are testing and content.

Last edited: Mar 22, 2024 at 2:30 AM
27 22NurseKim_ATL, paul_denver, TinaHashiRN and 24 others
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Dr.SleepRoch
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Mar 22, 2024 at 12:09 AM#3
mike_nyc said:
The useful checklist is about verifiability rather than presentation.

I disagree that testing history is decisive. It tells you what a supplier did when they were being watched. Continuity of behaviour under stress — a late shipment, a failed test, a complaint — is more predictive than any run of good results.

26 21Dr.NephBHM_UK, kim_atl_prep, sarah_TO and 23 others
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Dr.SportsMedIN
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Mar 22, 2024 at 12:48 AM#4

Short answer first, then the reasoning. The pattern that distinguishes a bad batch from an exit is behaviour rather than product. A bad batch comes with communication, a reshipment offer and a batch number. An exit comes with slower replies, pressure toward less reversible payment methods, sudden discounting, and the same reassurance repeated without any new information. The product tells you less than the correspondence does.

Last edited: Mar 22, 2024 at 5:48 AM
25 20Dr.SurgeonPGH, rachel_ABQ, traveltech_sara and 22 others
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hank_denver
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Mar 22, 2024 at 4:27 AM#5
SarahChen_PharmD said:
Prices dramatically below market are the strongest single signal, and the reason is arithmetic rather than suspicion.

This matches mine closely enough to be worth saying so. One addition: an unstated method makes a report close to uninterpretable. "99% pure" without the technique, the standard and the conditions is a claim, not a measurement.

24 19Dr.DermMIA, fiona_VT, denise_HTX and 21 others
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