Dr.ReproEndo said:
I will push back on the powder-first advice.
Adding the part of the answer the thread has not reached. The mental-health dimension is under-measured in the trial literature and the reports here are consistent enough to take seriously. On the positive side: reduced anxiety around food, better self-image, more confidence. On the difficult side: grief for the years lost, identity disruption, relationships built around eating, and the loss of food as a coping mechanism with nothing put in its place. Rarer but real: anhedonia and emotional flatness. Regulators have started asking for validated patient-reported outcomes in this class; the existing data gap is not evidence of absence.
Worth separating that from mood and mental health, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.
Last edited: Mar 7, 2025 at 5:28 AM