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ForumsSide Effects & ManagementGLP-1 and gastroparesis — what worked for you?

GLP-1 and gastroparesis — what worked for you?

PeptideSynthNJ Thu, Apr 18, 2024 at 5:47 PM 13 replies 2,009 viewsPage 1 of 3
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PeptideSynthNJ
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Apr 18, 2024 at 5:47 PM#1

I added fiber, made it noticeably worse, and only later worked out that I had added the bulk without adding the water.

What would genuinely help is knowing whether fiber actually helps GLP-1 constipation or whether the evidence is borrowed from a different population.

Tell me what I have not thought of.

1 21wanda_boise
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Dr.GastroMayo
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Apr 18, 2024 at 5:56 PM#2

Answering the narrow version, because the broad one does not have a single answer. The escalation order that reflects the mechanism: water and salt first, then soluble fiber, then magnesium or an osmotic agent, then a stimulant only briefly and only if the osmotic has failed. Stimulants first is the commonest error and the one most likely to end in a cycle of dependence.

50 20VendorMark, COA_Karl, MikeFit_NJ and 47 others
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PeptideChemSF
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Apr 18, 2024 at 6:05 PM#3
Dr.GastroMayo said:
The escalation order that reflects the mechanism: water and salt first, then soluble fiber, then magnesium or an osmotic agent, then a stimulant only…

Sulfur burps on constipation — the most underrated side effect nobody warned me about. 🤢 The smell is absolutely vile and comes on without warning.

What finally helped: taking a digestive enzyme supplement. Also, eating smaller portions and chewing thoroughly reduces the gas production.

If sulfur burps persist beyond 2-3 weeks, talk to your provider — it could indicate gastroparesis that needs medical attention.

49 19FDA_TrackerJim, ricardo_MIA, BrianDallas92 and 46 others
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MikeKY_noInsulin
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Apr 18, 2024 at 6:14 PM#4
PeptideSynthNJ said:
I added fiber, made it noticeably worse, and only later worked out that I had added the bulk without adding the water.

This matches mine closely enough to be worth saying so. Fiber trials in this population are thin, and most of what gets quoted is extrapolated from idiopathic constipation in people eating normally. The extrapolation is not unreasonable but it is an extrapolation, and it fails specifically for insoluble fiber at low intake — the case that comes up here most often.

48 18amy_econ_NJ, bbq_ray_KC, oliver_london and 45 others
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VendorMark
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Apr 18, 2024 at 7:00 PM#5

Adding the clinical framing, because it changes how the question reads.

Gastroparesis symptoms with constipation: the delayed gastric emptying from GLP-1 agonists can cause early satiety, bloating, and feeling "full" for hours after a small meal.

Tips: eat your protein FIRST (most important macro), then vegetables, then carbs last. Chew thoroughly — 20-30 chews per bite isn't excessive. Avoid carbonated beverages with meals. If symptoms are severe, your doctor may recommend a gastric emptying study.

47 17claudia_zurich, nancy_portland, rick_sfbay and 44 others
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