🍪 The GLP Lounge uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsSide Effects & ManagementConstipation on GLP-1: pathophysiology and fiber protocol — anyone have experience? Page 3

Constipation on GLP-1: pathophysiology and fiber protocol — anyone have experience?

SallyK_inj Tue, Jul 9, 2024 at 4:00 AM 26 replies 2,000 viewsPage 3 of 6
wanda_boise
Member
412
1,890
Aug 2024
Boise, ID
Jul 13, 2024 at 3:29 AM#11
DeniseRN_TPA said:
Fiber trials in this population are thin, and most of what gets quoted is extrapolated from idiopathic constipation in people eating normally.

Bookmarking. The distinction being drawn above is the one nobody else makes. Adding it to my notes with a link back to this thread.

43 16DanielChem_CHI, marco_milano, pam_columbus and 40 others
Reply Quote Save Share Report
VanRx_Mike
Member
678
2,890
May 2024
Vancouver, CA
Jul 13, 2024 at 4:18 PM#12

From the other side of the consultation, briefly.

Heartburn management on constipation: Gaviscon before bed has been my savior. The delayed gastric emptying means stomach acid just sits there.

Don't ignore persistent heartburn — chronic acid exposure can damage your esophagus. If OTC remedies aren't cutting it after 2 weeks, see your doctor for something stronger. You shouldn't suffer through this.

Last edited: Jul 13, 2024 at 7:18 PM
44 17MikeNYC_runner and 41 others
Reply Quote Save Share Report
Dr.ReproEndo
Senior Member
1,890
8,901
Jan 2024
Scottsdale, AZ
Jul 14, 2024 at 5:08 AM#13
PedsEndoPhilly said:
Acid reflux and constipation: I developed GERD symptoms around week 4 that I'd never had before.

Drug interaction alert relevant to constipation: if you take oral levothyroxine (Synthroid), GLP-1 agonists can reduce absorption due to delayed gastric emptying. My TSH drifted up after starting semaglutide.

Solution: take levothyroxine on an empty stomach, 60 minutes before any food, and have your TSH rechecked 6-8 weeks after starting or changing GLP-1 dose. My endo had to increase my Synthroid by 12.5mcg.

45 18Dr.EndoEP, GraceAZ_72, carl_compliance and 42 others
Reply Quote Save Share Report

Janoshik Analytical — Independent Testing

Trusted third-party HPLC & mass spectrometry analysis. Verify peptide purity with the lab the community relies on. Independent. Accurate. Transparent.

Verify Your Peptides

GL Biochem (Shanghai) Ltd. — Direct Manufacturer

Est. 1998. The synthesis house behind the vials you send for testing. ISO 9001 and cGMP certified, 1,500+ staff, batch-specific COA with every order.

Browse GL Biochem
Dr.PulmRoch
Member
456
2,345
Jun 2024
Rochester, MN
Jul 14, 2024 at 5:58 PM#14
SallyK_inj said:
The mechanism is slowed transit plus reduced intake, and that combination determines which interventions work.

Sulfur burps on constipation — the most underrated side effect nobody warned me about. 🤢 The smell is absolutely vile and comes on without warning.

What finally helped: Gas-X (simethicone) daily. Also, eating smaller portions and chewing thoroughly reduces the gas production.

If sulfur burps persist beyond 2-3 weeks, talk to your provider — it could indicate gastroparesis that needs medical attention.

Last edited: Jul 14, 2024 at 6:58 PM
46 19DebRD_ATL, KristenIndy, MarkLI_maint and 43 others
Reply Quote Save Share Report
mike_mod
Moderator
7,234
19,823
Nov 2023
New York
Online
Jul 15, 2024 at 6:48 AM#15

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Thread quality here is what the rules are for. Keep it up.

Last edited: Jul 15, 2024 at 8:48 AM
47 20PurityPaulOR, MaxMetOK, MounjBrad and 44 others
Reply Quote Save Share Report

Similar Threads

Nausea incidence by dose tier — STEP and SURMOUNT meta-analysis16 replies
Constipation on GLP-1: pathophysiology and fiber protocol5 replies
Alopecia on GLP-1 — telogen effluvium differential diagnosis3 replies
Gallbladder disease risk — cholelithiasis data from clinical trials12 replies
Pancreatitis risk assessment — pooled safety analysis15 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register