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ForumsMASH / Liver DiseaseSemaglutide and MASH — March 2026 Page 6

Semaglutide and MASH — March 2026

sophie_paris Tue, Dec 17, 2024 at 7:15 PM 42 replies 2,138 viewsPage 6 of 9
Dr.LeslieOBGYN
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Mar 20, 2025 at 3:05 AM#26

Adding the clinical framing, because it changes how the question reads. Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third retelling.

33 6Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 30 others
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carlos_SATX
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San Antonio, TX
Apr 1, 2025 at 11:18 AM#27
Dr.LeslieOBGYN said:
Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

This is my experience too, for whatever a second data point is worth.

Last edited: Apr 1, 2025 at 1:18 PM
34 7FranDenver, Dr.BariatricHTX, LindaRN_retired and 31 others
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LondonLisa
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London, UK
Apr 13, 2025 at 7:24 PM#28
Dr.LeslieOBGYN said:
Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

There is a second half to this that has not been said yet. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

35 8RetaRick_CA, JenPlateau, SallyK_inj and 32 others
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lucas_SP_BR
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Apr 26, 2025 at 3:23 AM#29

Adding the numbers, since they settle part of this. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

Last edited: Apr 26, 2025 at 5:23 AM
36 9KarenAZ_mom, zoe_NC, Dr.ObesityLA and 33 others
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sophie_paris
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Paris, FR
May 8, 2025 at 11:15 AM#30

Reporting back.

Update. I did go to 2.4mg in the end, and the honest report is that it bought me less than the step before it and cost me two bad weeks. Worth knowing rather than worth repeating.

Last edited: May 8, 2025 at 4:15 PM
8 6BethLabQueen, ChrisMacros, KetoKyle and 5 others
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