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Evidence-based GLP-1 & peptide discussion since 2023
ForumsProgress & Lab ResultsHas anyone dealt with triglycerides dropped 200 points?

Has anyone dealt with triglycerides dropped 200 points?

carl_compliance Sat, Jan 3, 2026 at 6:45 PM 26 replies 1,353 viewsPage 1 of 6
carl_compliance
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Jan 3, 2026 at 6:45 PM#1

Putting this up for argument rather than for agreement. I have read it twice and I am still not certain what it supports.

ApoB is the more informative number and it is cheap. LDL-C estimates cholesterol mass in atherogenic particles; ApoB counts the particles, and it is particle count that tracks risk — which is why the two can disagree and why the disagreement is the clinically interesting case. Triglycerides fall substantially with weight loss and improved insulin sensitivity, HDL moves modestly, and LDL-C often barely moves at all, which surprises people who expected everything to improve together.

Where I think it is weakest: the completion rate deserves as much attention as the headline, because a large effect among those who finished is a different claim from a large effect among those enrolled.

The question I want answered is whether an unchanged LDL-C alongside a large triglyceride fall is a good result or a bad one, because ApoB and LDL-C seem to be telling different stories. Numbers rather than impressions, if you have them.

Note on sourcing:
Figures above are from the primary publication rather than the press summary. If a number here disagrees with one you have, post yours and we will work out which of us is reading a secondary source.
22 17labquiet_amy, emily_PDX, Dr.SleepRoch and 19 others
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Dr.SportsMedIN
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Jan 3, 2026 at 7:01 PM#2
carl_compliance said:
ApoB is the more informative number and it is cheap.

Omega-3 index improvement on the lipid panel: often overlooked but my omega-3 index went from 4.3% to 8.3% over 10 months. I supplemented with 2g EPA+DHA daily.

This matters because omega-3s are anti-inflammatory and cardioprotective, complementing the GLP-1 benefits. Target omega-3 index is >8%. Combined with the triglyceride reduction from the medication, my lipid profile is the best it's been in decades.

Last edited: Jan 4, 2026 at 12:01 AM
21 16lisa_labSD, adam_van, Dr.SurgeonPGH and 18 others
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Dr.ObesityLA
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Jan 3, 2026 at 7:17 PM#3
carl_compliance said:
ApoB is the more informative number and it is cheap.

Careful with treating an unchanged LDL-C as a failure. If ApoB and triglycerides both fell, the particle picture improved regardless of what the calculated LDL says.

That is the short version; the long version is somebody else's post.

20 15tampaLisa73, KarenAZ_mom, zoe_NC and 17 others
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lisa_labSD
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Jan 3, 2026 at 7:33 PM#4
Dr.ObesityLA said:
Careful with treating an unchanged LDL-C as a failure.

Advanced lipoprotein testing on the lipid panel — going beyond standard lipid panel:

MarkerBaselineMonth 8Clinical Meaning
LDL-P1669969Particle count (more precise than LDL-C)
Small dense LDL59%33%Atherogenic pattern
Remnant cholesterol3318Triglyceride-rich lipoproteins
oxLDL7447Oxidative stress marker

The shift from small dense to large buoyant LDL is particularly important — it represents a fundamental change in the atherogenic profile.

19 14lori_vegas, Dr.PulmRoch, maya_sedona and 16 others
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FitDadDave
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Jan 3, 2026 at 8:56 PM#5
Dr.SportsMedIN said:
Omega-3 index improvement on the lipid panel: often overlooked but my omega-3 index went from 4.3% to 8.3% over 10 months.

This is my experience too, for whatever a second data point is worth.

18 13jason_paloalto, Dr.LeslieOBGYN, MikeNYC_runner and 15 others
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