Oral semaglutide 25mg vs 50mg — looking for input

MASHdoc_SA said:

Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

Coming at MASHdoc_SA’s question from a different direction. Steady state is the thing most people miss. The terminal half-life is about a week, so every dose step takes four to five weeks to fully express itself. Judging a step at day ten is judging the ascent, not the plateau, and it is the single commonest reason people escalate before they needed to.

Worth separating that from semaglutide, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

Adding the numbers, since they settle part of this. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

One thing that is still open after MASHdoc_SA’s answer:

What the dose-response curve actually looks like above 1.7mg, because the trial means hide how few people account for the extra loss?

stefan_berlin said:

For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

This is where I part company with the consensus forming above. Pushing back on the consensus forming here. Consistency is not the same as correctness, and a board that agrees with itself quickly is usually agreeing with the first person who sounded certain.

stefan_berlin said:

For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

No disagreement, though it depends on where somebody is starting from, and this thread has been assuming a starting point nobody stated.