Adding the clinical framing, because it changes how the question reads. The distinction that resolves most of these threads is between what is true on average and what is true for one person. Both are real; they answer different questions and get quoted as if they were the same one.
Dr.CardioMD said:The distinction that resolves most of these threads is between what is true on average and what is true for one person.
This matches mine closely enough to be worth saying so out loud.
Dr.CardioMD said:The distinction that resolves most of these threads is between what is true on average and what is true for one person.
Adding the part of the answer the thread has not reached. HbA1c reflects roughly three months of average glycaemia weighted toward the most recent weeks, which is why repeating it at six weeks tells you very little. The improvement on this class comes from two directions — direct glucose-dependent insulin secretion and glucagon suppression, plus the indirect effect of weight loss on insulin sensitivity — and the second continues after the first has plateaued.
Happy to go further on any of that.
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Browse GL BiochemThe figures, for anyone assembling their own picture. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.
One thing that is still open after Dr.CardioMD’s answer:
Why A1C lags the way it does, and what to look at in the meantime if you want to know sooner?