Clinical perspective, offered as context rather than as advice. The version of this that has an answer is narrower than the version being asked. Narrow it and it becomes tractable; leave it broad and the thread will produce nine confident and incompatible replies.
If somebody has the primary source to hand I would rather cite it than paraphrase it.
Following on from emily_PDX — and this may be the naive question:
What did you change at the same time, and can you separate the two now?
Dr.DermMIA said:The version of this that has an answer is narrower than the version being asked.
I read this differently from Dr.DermMIA, on substance rather than tone. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.
Ask again with the specifics and you will get a better answer than this one.
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Browse GL BiochemDr.DermMIA said:The version of this that has an answer is narrower than the version being asked.
Fair, and it stops being fair at the extremes. The middle of the range is well understood; the ends are where the honest answer is that nobody knows.
Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful.