Clinical perspective, offered as context rather than as advice. The distinction that resolves most of these threads is between what is true on average and what is true for one person. Both are real; they answer different questions and get quoted as if they were the same one.
One thing that is still open after PharmD_Rodriguez’s answer:
How much of the between-person variation is pharmacokinetic and how much is just adherence measured badly?
Dr.PeteFamMed said:The distinction that resolves most of these threads is between what is true on average and what is true for one person.
Pushing back on Dr.PeteFamMed here. The mechanism that matters here is not stomach emptying, it is central. GLP-1 receptor agonism in the arcuate nucleus stimulates POMC neurons and suppresses AgRP/NPY signalling, which is why the effect is appetite and food salience rather than physical fullness. Delayed gastric emptying largely tachyphylaxes over the first months; the appetite effect does not.
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Browse GL BiochemDr.PeteFamMed said:The distinction that resolves most of these threads is between what is true on average and what is true for one person.
That is correct as far as it goes, and here is where it stops going. Yes, and the corollary is less popular: if the reasoning holds, it also holds where it produces an answer we do not like.
Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Carry on.