Semaglutide and MASH — what worked for you?

DebRD_ATL said:

The liver data is among the strongest non-weight findings in the class.

All true, with one condition: that curve is for people who reached the dose on schedule. Anyone who slowed the ladder for tolerability is on a different, flatter curve, and comparing yourself with the published mean will make you feel like a non-responder when you are not.

denise_HTX said:

The dose-response is real but shallow at the top.

This answered a question I did not know how to ask. Adding it to my notes with a link back to this thread.

DebRD_ATL said:

The liver data is among the strongest non-weight findings in the class.

Pushing back on DebRD_ATL here. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.

The figures, for anyone assembling their own picture. With resmetirom now available for MASH, combination approaches are being explored, so the standard of care in this area is moving faster than most threads assume.

That is the short version; the long version is somebody else's post.

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Tagging this one for the weekly digest.