Dr.SurgeonPGH said:Dr.AddMedPHL said: ...the muscle loss concern with lean mass...
OMG yes. lean mass + resistance training is the combo. Can confirm.
andrew_nyc said:Right, and protein targets should be set on a reference weight rather than current weight.
Saving this. It is the first explanation that did not require me to already understand it. Taking it to my next appointment.
Dr.SurgeonPGH said:Dr.AddMedPHL said: ...the muscle loss concern with lean mass...
Bone density monitoring on lean mass: DEXA bone density at baseline and month 12.
Lumbar spine T-score: -0.11 → -0.8 (stable to slightly improved)
Femoral neck T-score: -0.11 → -0.9 (stable)
No significant bone loss despite 58 lbs of weight loss. Key factors: adequate calcium (1200mg/day), vitamin D (5000 IU/day), resistance training 3x/week, and adequate protein. Weight-bearing exercise is critical for maintaining bone density during rapid weight loss.
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View Resultsdave_SLC said:Two DEXA scans eleven months apart: down 24kg total, of which the scan says 6kg was lean.
Sharing my comprehensive lab data relevant to lean mass:
| Biomarker | Baseline | Month 3 | Month 6 | Month 9 |
|---|---|---|---|---|
| Weight (lbs) | 257 | 247 | 217 | 212 |
| A1C (%) | 7.2 | 6.7 | 6.2 | 5.4 |
| hsCRP (mg/L) | 7.0 | 4.0 | 2.5 | 1.3 |
| Triglycerides | 197 | 157 | 117 | 97 |
Protocol: Tirzepatide 10mg/wk, resistance training 5x/week, protein 1.5g/kg/day.
The improvements in lean mass are clearly reflected in these numbers. The inflammatory marker reduction (hsCRP) is particularly striking.