From the other side of the consultation, briefly. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.
From the other side of the consultation, briefly. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.
Dr.RenalNash said:The mechanism and the magnitude are separate questions.
Can confirm. Same sequence, different timescale.
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Browse GL BiochemDr.RenalNash said:The mechanism and the magnitude are separate questions.
There is a second half to this that has not been said yet. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.
If somebody has the primary source to hand I would rather cite it than paraphrase it.