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ForumsMASH / Liver DiseaseMASH resolution without worsening fibrosis — need advice Page 3

MASH resolution without worsening fibrosis — need advice

NicoleRaleigh Sun, Dec 28, 2025 at 10:21 AM 11 replies 1,070 viewsPage 3 of 3
amy_econ_NJ
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Dec 31, 2025 at 2:56 PM#11
jim_asheville said:
Liver enzyme update related to liver and MASH: I had mildly elevated ALT/AST at baseline (likely NAFLD).

Bookmarking. The distinction being drawn above is the one nobody else makes. Taking it to my next appointment.

37 10Dr.SportsMedIN, amy_econ_NJ, bbq_ray_KC and 34 others
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BariatricNurseD
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Dec 31, 2025 at 10:22 PM#12

Clinical perspective, offered as context rather than as advice. The useful move here is to separate what is established from what is widely repeated. Those two sets overlap less than the confident tone of most write-ups suggests, and the second set is where nearly all the disagreement on this board comes from.

38 11roxy_nash, tony_orlando, Dr.NephBHM_UK and 35 others
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Dr.RenalNash
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Jan 1, 2026 at 5:48 AM#13
newstart_MO said:
ATTAIN trial (survodutide) context for liver and MASH: survodutide, a GLP-1/glucagon dual agonist, showed -18.7% body weight at 46 weeks in the Phase…

Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.

39 12Dr.NutriCornell, pam_stl, wei_SG and 36 others
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PharmacoVig_BOS
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Jan 1, 2026 at 1:14 PM#14

Adding the numbers, since they settle part of this. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

40 13kate.chem, DataDave, Dr.GutHealth and 37 others
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Admin
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Jan 1, 2026 at 8:39 PM#15

Moderator note: a couple of off-topic posts removed.

41 14PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 38 others
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