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ForumsMASH / Liver DiseaseHas anyone dealt with alt normalization rates on glp-1? Page 3

Has anyone dealt with alt normalization rates on glp-1?

laura_annarbor Fri, Jan 9, 2026 at 9:24 PM 23 replies 1,414 viewsPage 3 of 5
PharmD_Rodriguez
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Jan 12, 2026 at 5:54 PM#11
MASHdoc_SA said:
If two explanations both fit, the useful question is which one predicts something the other does not.

Agreed on the substance. I would put less weight on the timescale, because two months of anything is not enough to distinguish a trend from a wobble.

Last edited: Jan 12, 2026 at 10:54 PM
8 6paul_denver, TinaHashiRN, robert_kc and 5 others
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tom_AK
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Jan 13, 2026 at 5:58 AM#12
robert_kc said:
NASH/MAFLD therapeutic landscape and liver and MASH: GLP-1 agonists are emerging as potential first-line NASH therapy.

This answered a question I did not know how to ask.

Last edited: Jan 13, 2026 at 9:58 AM
9 7VanRx_Mike, steve_okc, dave_SLC and 6 others
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BethLabQueen
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Jan 13, 2026 at 6:02 PM#13
MASHdoc_SA said:
If two explanations both fit, the useful question is which one predicts something the other does not.

Pushing back on MASHdoc_SA here. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

10 8lori_vegas, Dr.PulmRoch, maya_sedona and 7 others
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quinn_sf
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Jan 14, 2026 at 6:06 AM#14

Adding the numbers, since they settle part of this. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

11 9andrew_nyc, Dr.EndoEP, GraceAZ_72 and 8 others
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Admin
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Jan 14, 2026 at 6:09 PM#15

Moderator note: a couple of off-topic posts removed.

Last edited: Jan 14, 2026 at 10:09 PM
12 10PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 9 others
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