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ForumsSide Effects & ManagementMood changes on GLP-1 — depression, anxiety, or medication effect? Page 4

Mood changes on GLP-1 — depression, anxiety, or medication effect?

Dr.AddMedPHL Tue, May 19, 2026 at 7:17 PM 19 replies 547 viewsPage 4 of 4
CarlaRPh_TPA
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May 25, 2026 at 1:16 PM#16
claudia_zurich said:
One year anniversary on mental health — reflections: What I wish I'd known: the side effects are temporary, the benefits compound over time, protein…

Adding a me-too, because a thread of one person's experience is not much use. The detail I would add is minor and it is already implied above.

Last edited: May 25, 2026 at 5:16 PM
14 12FDA_TrackerJim, ricardo_MIA, BrianDallas92 and 11 others
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KetoKyle
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May 25, 2026 at 8:49 PM#17
stefan_berlin said:
Anxiety increase on mental health: counterintuitive, but losing weight rapidly triggered anxiety for me.

Before/after narrative for mental health — one year in:

Before (263 lbs): Winded climbing stairs, chronic back pain, pre-diabetic, on 3 medications, dreaded mirrors, avoided photos, social anxiety about my weight.

After (193 lbs): Run 3 miles regularly, pain-free, A1C normal, down to 1 medication, bought a swimsuit for the first time in a decade, actually enjoy being photographed.

Total weight lost: 93 lbs. Total life gained: immeasurable. This isn't just about weight — it's about reclaiming your identity.

Last edited: May 25, 2026 at 9:49 PM
15 13JenMemphis, pat_auckland, Dr.GastroMayo and 12 others
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AttorneyGrant
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May 26, 2026 at 4:22 AM#18
stefan_berlin said:
Anxiety increase on mental health: counterintuitive, but losing weight rapidly triggered anxiety for me.

Positive side effects of mental health that surprised me:

  1. Clearer skin — inflammation reduction improved my rosacea
  2. Better sleep — weight loss resolved mild sleep apnea
  3. Improved libido — better body image + improved cardiovascular health
  4. Less joint pain — obvious mechanical benefit
  5. More energy — metabolic improvements across the board

Not everything about GLP-1 therapy is a struggle. There are genuinely wonderful changes too. ✨

Last edited: May 26, 2026 at 5:22 AM
16 14JenMemphis, pat_auckland, Dr.GastroMayo and 13 others
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JessicaH_TX
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May 26, 2026 at 11:55 AM#19
stefan_berlin said:
Anxiety increase on mental health: counterintuitive, but losing weight rapidly triggered anxiety for me.

That reframing is the part I needed. Adding it to my notes with a link back to this thread.

Last edited: May 26, 2026 at 3:55 PM
17 15Dr.NephBHM_UK, kim_atl_prep, sarah_TO and 14 others
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mike_mod
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May 26, 2026 at 7:28 PM#20

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again.

Last edited: May 26, 2026 at 9:28 PM
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