Clinical perspective, offered as context rather than as advice. Take it one variable at a time. Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent argument can untangle them after the fact.
Dr.RaviCardio said:Say what you would expect to see if you were wrong, before you look.
This answered a question I did not know how to ask. I will report back once I have actually tried it.
From the other side of the consultation, briefly. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.
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View Resultsanders_CPH said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
This matches mine closely enough to be worth saying so. Steady state is the thing most people miss. The terminal half-life is about a week, so every dose step takes four to five weeks to fully express itself. Judging a step at day ten is judging the ascent, not the plateau, and it is the single commonest reason people escalate before they needed to.